The growth of the world population and rapid technological advancement, especially in the industrial sector, have considerably increased energy demand. Conventional power generation has caused many social and environmental problems. Two main approaches to solving these problems are to use renewable energy sources, such as solar energy, and to recover waste heat from various processes. Solar energy is a potential alternative to traditional fuels for electricity generation due to its low environmental impact and wide availability in many parts of the world. In contrast, waste-heat recovery is critical for reducing energy losses and improving energy management. One way to make use of these energy sources is the Organic Rankine Cycle (ORC). The ORC is similar to the traditional Rankine cycle, except that organic fluids are used as the working fluid. In this study, energy and exergy analyses of a solar/waste-heat-driven hybrid ORC are performed for four working fluids and four waste-heat temperature levels. Power output, thermal efficiency, and energy and exergy efficiencies are compared under different operating conditions. The results indicate that toluene provides the highest net power output, the highest first-law efficiency of the whole System, and the second-law first- and second-law efficiencies of the cycle among the considered working fluids. The performance of Cyclohexane, MDM, and n-pentane is comparable.